Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2504702 | International Journal of Pharmaceutics | 2009 | 4 Pages |
Abstract
The solubilisation of two poorly soluble flavonoids, quercetin and rutin, in micellar solutions of mixtures of a block copolymer of ethylene oxide and styrene oxide (E137S18E137) with one of ethylene oxide and propylene oxide (E62P39E62) has been studied at 25 and 37 °C. Solubilisation capacities were higher than those for the model poorly water-soluble drug griseofulvin and comparable with published values for the solubilisation of rutin by β-cyclodextrin.
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Authors
Maria Elenir N.P. Ribeiro, Ícaro G.P. Vieira, Igor Marques Cavalcante, Nágila M.P.S. Ricardo, David Attwood, Stephen G. Yeates, Colin Booth,