| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2504765 | International Journal of Pharmaceutics | 2009 | 7 Pages |
Abstract
Novel pH-responsive flower-like micelles were developed to provide the mechanism for pH-triggered drug release from drug carriers. The micelles (particle size: ∼165 nm; critical micelle concentration (CMC): ∼4 μg/ml), constructed from poly(Nɛ-(3-diethylamino)propyl isothiocyanato-l-lysine)-b-poly(ethylene glycol)-b-poly(l-lactide) [poly(DEAP-Lys)-b-PEG-b-PLLA], were designed to have a self-assembled flower-like arrangement consisting of two hydrophobic blocks [deprotonated poly(DEAP-Lys) block and PLLA block] and a petal-like hydrophilic PEG block at physiological pH. As the pH decreases to slightly acidic pH (
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Authors
Kyung Taek Oh, Young Taik Oh, Nam-Muk Oh, Kwangmyung Kim, Don Haeng Lee, Eun Seong Lee,