| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2505064 | International Journal of Pharmaceutics | 2009 | 6 Pages |
Abstract
The use of 1H NMR experiments to determine the solubility of potential drug candidates using a panel of solubilizing agents is proposed as an alternative to an HPLC-UV method. The advantages of using this approach will be discussed and results comparing the two methodologies will be presented. This effort highlights the importance of a simple method for determining a suitable formulation for discovery compounds for studies using a minimal amount of material in support of early in vivo studies.
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Authors
Melissa Lin, Marc Tesconi, Mark Tischler,