Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2505148 | International Journal of Pharmaceutics | 2008 | 4 Pages |
Abstract
The dependence of log(cmc) on hydrophobic block length n was examined for EmBn copolymers (E = oxyethylene, B = oxybutylene, subscripts denote number-average block lengths in repeat units) with n in the range 30–76. Combination with published data for EmBn diblock copolymers with shorter E-blocks shows two changes of slope in the log(cmc)–n plot corresponding to the onset of unimolecular micelle formation at n ≈ 12 and completion of this process at n ≈ 30. The results are discussed with reference to published data for EmLn and EmCLn (L from d,l-lactide; CL from ɛ-caprolactone) copolymers, which show similar behaviour.
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Authors
Maria Elenir N.P. Ribeiro, Samira A. de Oliveira, Nágila M.P.S. Ricardo, Shao-Min Mai, David Attwood, Stephen G. Yeates, Colin Booth,