Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2505201 | International Journal of Pharmaceutics | 2008 | 7 Pages |
Abstract
A topological–mathematical model has been arranged to search for new derivatives of deoxyuridine and related compounds acting as antimalarials against Plasmodium falciparum. By using linear discriminant and multilinear regression analysis a model with two functions was capable to predict adequately the IC50 for each compound of the training and test series. After carrying out a virtual screening based upon such a model, new structures potentially active against P. falciparum are proposed.
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Authors
Ramón García-Domenech, Wanda López-Peña, Yessenia Sanchez-Perdomo, José R. Sanders, Mercedes M. Sierra-Araujo, Claudy Zapata, Jorge Gálvez,