Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2505659 | International Journal of Pharmaceutics | 2008 | 4 Pages |
Abstract
The effect of dimethyl sulfoxide (DMSO) and its nearest homologue diethyl sulfoxide (DESO) as a polar cosolvents on the binding of vitamin E to water + DMSO (DESO) containing reversed micelles of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) has been investigated by a spectrophotometric method.The results suggest that compare with water without organic cosolvent-containing reversed micelles in this case an increase of binding constant of vitamin E in reversed micelles takes place.The results obtained shown that with the addition of DMSO and DESO it will be possible to monitoring a penetration of vitamin E into micellar core.
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Authors
S.A. Markarian, J.D. Grigoryan, H.R. Sargsyan,