| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2506259 | International Journal of Pharmaceutics | 2007 | 8 Pages |
Abstract
A new peroral amoxicillin/clavulanate therapeutic system composed of immediate release tablet and controlled release floating capsule was developed and evaluated by in vivo bioavailability study. Pharmacokinetic (PK) parameters for amoxicillin and clavulanic acid of the new therapeutic systems: AUCt, AUCi, (AUCt/AUCi), Cmax, Tmax, kel, T1/2 and additionally for amoxicillin T4 and T2 were calculated from the plasma levels. The study confirmed enhanced pharmacokinetic parameters of a newly developed therapeutic system containing 1500 mg of amoxicillin and 125 mg of clavulanic acid. Prolonged time over MIC of amoxicillin in relation to a regular immediate release amoxicillin/clavulanate formulation was confirmed.
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Authors
Janez Kerč, Jerneja Opara,