A new copolymer membrane controlling clonidine linear release in a transdermal drug delivery system

A new type of copolymer membranes was prepared through photosynthesis of mixtures of three different monomers. The membranes present a linear permeation property in clonidine transdermal drug delivery system. Monomers used in the photosynthesis were 2-hydroxy-3-phenoxypropylacrylate, 4-hydroxybutyl acrylate and sec-butyl tiglate. Permeation property of the membranes with different monomer ratios and thickness were investigated. When clonidine concentrations were in 3.0–5.0 mg/ml range, membranes showed near zero order permeation rates. An optimized membrane was characterized by FTIR, DSC and SEM.