Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2507756 | Journal of Pharmaceutical Analysis | 2015 | 7 Pages |
Abstract
Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies (IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins, calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers.
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Authors
Baishakhi Dey, Prakash Katakam, Fathi H. Assaleh, Babu Rao Chandu, Shanta Kumari Adiki, Analava Mitra,