Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2508055 | Journal of Pharmaceutical Analysis | 2012 | 7 Pages |
Abstract
Electrochemical reduction behavior of Adefovir was studied using Hanging Mercury Drop Electrode (HMDE) in Britton–Robinson (BR) buffer solution. Voltammetric study showed one well-defined reduction peak in the potential range −1.2 to −1.4 V (vs. Ag/AgCl) due to reduction of C=N bond of the imidazole ring. Solid-phase extraction and protein-precipitation techniques were employed for extraction of Adefovir from human plasma. The proposed method allows quantification of Adefovir in human plasma over the concentration range 0.50–5.00 μg/mL with the detection limit 0.17 μg/mL, whereas in pharmaceutical formulation 0.25–2.25 μg/mL with the detection limit 0.08 μg/mL.
Keywords
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Authors
Rajeev Jain, Ramkishor Sharma,