Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2509644 | Saudi Pharmaceutical Journal | 2012 | 9 Pages |
Abstract
A series of hybrid novel chloro (1a–9a) and dichloro (10b–18b) phenylthiazolyl-s-triazine were synthesized and subsequently subjected to their antibacterial activity against three gram positive viz. Lactobacillus casei (NCIM-2651); Bacillus cereus (NCIM-2458); Staphylococcus aureus (NCIM-2120) and three gram negative viz Salmonella typhimurium (NCIM-2501); Escherichia coli (NCIM-2065); Klebsiella aerogenes (NCIM-2098). The SAR studies around the lead compound revealed that introduction of electron withdrawing groups and amino (–NH–) and mercapto (–S–) linker bridge seemed more promising towards antibacterial activity. Moreover, the virtual Molinspiration screenings are in compliance with Ghose’s rule.
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Prashant Gahtori, Surajit Kumar Ghosh, Brijesh Singh, Udaya Pratap Singh, Hans Raj Bhat, Archana Uppal,