| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2509693 | Saudi Pharmaceutical Journal | 2009 | 4 Pages |
Abstract
Novel pyrimidines were prepared by the condensation of chalcones of 4′-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1–5 were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine.
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmaceutical Science
Authors
Sk.A. Rahaman, Y. Rajendra Pasad, Phani Kumar, Bharath Kumar,