RETRACTED: Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the Editor.Figure 1A (3rd lane; CDC) was manipulated by replicating an image of a control lane from Figure 1C (left lane) to represent different experimental conditions.Figure 1D, nuclei isolated from cells in medium (“Nuclei / Medium”), was reused in Figure 1G in reference [1], to represent different experimental conditions (nuclei of cells treated with γ-T3; “Nuclei / γ-T3”).Images in Figure 5A were reused to represent different experimental conditions: curcumin uptake in KBM-5 cells treated with curcumin alone at 30 minutes, and curcumin uptake in KBM-5 cells treated with cyclodextrin-complexed curcumin (CDC) at 45 minutes.Images from Figure 5A were reused in Figure 2A of reference [2] to represent different experimental conditions: four of the control images of cellular uptake of curcumin shown in Figure 5A (45, 60, 120 and 180 min) are also shown in Figure 2A (45, 60, 120 and 180 min) of reference [2].The article has been retracted because the data integrity has become questionable.References[1] Kannappan R, Yadav VR, Aggarwal BB γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents J Biol Chem 285 2010 33520–33528 http://dx.doi.org/10.1074/jbc.M110.158378.[2] Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo Biochem Pharmacol 79 2010 330–338 http://dx.doi.org/10.1016/j.bcp.2009.09.003.