Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2513594 | Biochemical Pharmacology | 2010 | 8 Pages |
Abstract
Allograft rejection is a predominantly Th1 immune response. In this study, we showed that obaculactone, a natural compound derived from citrus fruit, prolonged skin graft survival in mice when treated after but not before transplantation. Furthermore, obaculactone inhibited alloantigen-specific production of Th1 cytokine IFN-γ as well as proinflammatory cytokine IL-2, TNFα and IL-6. In parallel, IL-10 production was markedly up-regulated. Obaculactone significantly enhanced the percentage of CD4+CD25+Foxp3+ Treg cells in the CD4+ splenocytes without any effect on their inhibitory function. In vitro and in vivo tests showed obaculactone down-regulated T-bet expression in Th1 effector cells. Taken together, the unique immunomodulatory properties might qualify obaculactone as a putative, therapeutic compound for the treatment of Th1-driven diseases, including transplant rejection.
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Authors
Fangyuan Gong, Yan Shen, Qi Zhang, Yang Sun, Jiayu Tang, Feifei Tao, Qiang Xu,