Deregulated NF-κB activity in haematological malignancies

The NF-κB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-κB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-κB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.