Cassane diterpenes with oxygen bridge from the seeds of Caesalpinia sappan

The seeds of the medicinal plant Caesalpinia sappan yielded fourteen cassane-type diterpenes, including six new rearranged ones named as caesalppans A-F (1–6). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated new compounds 1–6 possess lactone-type cassane diterpenoid skeleton with an oxygen bridge between C-19 and C-20, and were tested cytotoxic activity against four cancer cell lines using the MTT method.

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