Adeninealkylresorcinol, the first alkylresorcinol tethered with nucleobase from Lasiodiplodia sp.

Adeninealkylresorcinol (1), an unusual alkylresorcinol with adenine-alkylresorcinol conjoined skeleton, was isolated from an endophytic fungus Lasiodiplodia sp. obtained from a traditional Chinese medicine Houttuynia cordata Thunb., together with three new biogenetically related compounds (2–4). Their structures were elucidated by comprehensive spectroscopic analysis, and the absolute configuration of 4 was determined by the modified Mosher's method and quantum chemical calculation. Among them, adeninealkylresorcinol (1) is the first alkylresorcinol tethered with nucleobase. In addition, the antioxidant, cytotoxic, and antimicrobial activities of 1–3 were evaluated.

Graphical abstractAdeninealkylresorcinol (1), the first case of alkylresorcinol tethered with nucleobase, was isolated from an endophytic fungus Lasiodiplodia sp., together with three new biogenetically related compounds (2–4). The antioxidant, cytotoxic, and antimicrobial activities of 1–3 were evaluated and 1–3 showed potent antioxidant activity.Figure optionsDownload full-size imageDownload high-quality image (203 K)Download as PowerPoint slide