New sesquiterpenoids from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against α-glucosidase and PTP1B

Nine new sesquiterpenoids, clitocybulol derivatives, clitocybulols G–O (1–9) and three known sesquiterpenoids, clitocybulols C–E (10 − 12), were isolated from the solid culture of the edible fungus Pleurotus cystidiosus. The structures of compounds 1–12 were determined by spectroscopic methods. The absolute configurations of compounds 1–9 were assigned via the circular dichroism (CD) data analysis. Compounds 1, 6 and 10 showed moderate inhibitory activity against protein tyrosine phosphatase-1B (PTP1B) with IC50 values of 49.5, 38.1 and 36.0 μM, respectively.

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