Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2538133 | Fitoterapia | 2016 | 7 Pages |
Three new phenylnaphthalene-type lignans, vitexnegheteroins E-G (1–3), and a new polyoxygenated ursane-type triterpene, vitexnegheteroin H (9), were isolated from the seeds of Vitex negundo var. heterophylla, together with ten known compounds. Their structures were established on the basis of extensive 1D and 2D NMR experiments, as well as their mass spectroscopic data. The absolute configurations of compounds 1 and 2 were determined by comparing their experimental ECD spectra with that calculated by the time-dependent density functional theory (TDDFT) method. The isolates were evaluated for their cytotoxicities against three human cancer cell lines, inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells, and antioxidant activities for ABTS radical scavenging.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (383 K)Download as PowerPoint slide