Yuccalides A–C, three new phenolic compounds with spiro-structures from the roots of Yucca gloriosa

Three new phenolic compounds, yuccalides A–C (1–3), were isolated from the roots of Yucca gloriosa L., along with four known compounds (4–7). The structures of the new compounds were established by extensive NMR spectroscopic analyses. Inducible nitric oxide synthase (iNOS) mRNA levels induced by lipopolysaccharide (LPS) in mouse macrophage–like RAW 264.7 cells were effectively suppressed by compounds 2, 4, and 6, all of which had the (2R*, 3R*)-configuration. IL-1β and IL-6 mRNA levels induced by LPS were significantly attenuated by compounds 4, 5, and 6, but not by 2.

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