| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538178 | Fitoterapia | 2016 | 6 Pages |
Abstract
The triterpene esters ᴪ taraxasterol-3-O-myristate (1) and arnidiol-3-O-myristate (2) were tested for their ability to protect epithelial intestinal barrier in an in vitro model. Their effects on ROS production and on trans-epithelial resistance were investigated on CaCo-2 cell monolayers both in basal and stress-induced conditions. Both compounds were able to modulate the stress damage induced by H2O2 and INFγ + TNFα, showing a potential use as model compounds for the study of new therapeutic agents for intestinal inflammations.
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Authors
Stefano Dall'Acqua, Daniela Catanzaro, Veronica Cocetta, Nadine Igl, Eugenio Ragazzi, Maria Cecilia Giron, Laura Cecconello, Monica Montopoli,