6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity

Phytochemical analysis of Euphorbia sogdiana Popov, Euphorbiaceae, afforded the isolation of three new diterpenes based on the rare 6(17)-epoxylathyrane skeleton (1–3), along with a lathyrane (4), a myrsinane (5) and a tigliane (6) diterpenoids, previously isolated from Euphorbia aellenii. Their chemical structures were established through a combination of nuclear magnetic resonance spectroscopy and mass spectrometric methods. The epoxylathyranes 1–4 were tested to evaluate their cytotoxic activity against Jurkat T-leukemia and EJ-138 bladder cancer cells and their chemical analogy allowed to propose some structure activity relationships.

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