Elemanolide dimers from seeds of Vernonia anthelmintica

The seeds of Vernonia anthelmintica afforded three new elemanolide dimers, vernodalidimers C, D, and E, and four known elemanolides. Their structures were elucidated based on extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations of the new dimers were determined by comparison of the experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolated compounds against four human tumor cell lines was assayed. Vernodalidimers C, D, and E exhibited strong cytotoxicity against T47D cell line with IC50 values of 5.58, 0.95, and 12.75 μM, respectively.

Graphical abstractThree new elemanolide dimers, vernodalidimers C, D, and E, and four known elemanolides were isolated from the seeds of Vernonia anthelmintica. The absolute configurations of the dimers were determined by comparison of the experimental and calculated ECD spectra and the isolations were tested to cytotoxic activities against four human tumor cell lines.Figure optionsDownload full-size imageDownload high-quality image (277 K)Download as PowerPoint slide