Limonoids from Munronia henryi and their anti-tobacco mosaic virus activity

ABSTRACTFive new compounds (1–5), including three limonoids, one diterpenoid, and one phytosterol, along with four known limonoids (6–9), were isolated from the ethanolic extracts of whole plants of Munronia henryi. Their structures were elucidated by extensive spectroscopic analysis. In addition, the anti-tobacco mosaic virus (TMV) activities of all the isolated compounds were evaluated by the conventional half-leaf and leaf-disk methods along with Western blot analysis. Most of the tested compounds showed strong antiviral activities, with IC50 values in the range of 14.8–34.0 μg/mL, compared with ningnanmycin as a positive control (IC50 = 44.6 μg/mL), and their preliminary structure-activity relationships were also discussed.

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