| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538313 | Fitoterapia | 2015 | 5 Pages |
Abstract
Five new hexacyclic monoterpenoid indole alkaloids, rauvovertine A (1), 17-epi-rauvovertine A (2), rauvovertine B (3), 17-epi-rauvovertine B (4), and rauvovertine C (5) together with 17 known analogues were isolated from the stems of Rauvolfia verticillata. Compounds 1/2 and 3/4 were obtained as C-17 epimeric mixtures due to rapid hemiacetal tautomerism in solution. The structures of 1–5 were established by spectroscopic analysis and with the aid of molecular modeling. The new alkaloids were evaluated for their cytotoxicity in vitro against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines.
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Authors
Yuan Gao, Ai-Lin Yu, Gen-Tao Li, Ping Hai, Yan Li, Ji-Kai Liu, Fei Wang,