Flavonol dimers from callus cultures of Dysosma versipellis and their in vitro neuraminidase inhibitory activities

A chemical investigation of callus cultures of Dysosma versipellis led to the isolation of five new flavonol dimers, dysoverines A − E (1 − 5), together with 12 known compounds (6 − 17). The structures of new compounds were determined by the extensive spectroscopic data analyses. The biosynthetic pathway of the new compounds was proposed to involve O-methylation, prenylation, and Diels–Alder cycloaddition, which successively occurred in cultured plant cells. Compounds 1 − 17 exhibited in vitro neuraminidase inhibitory activities with the IC50 values of 31.0 − 93.9 μM.

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