Bioactive carbazole alkaloids from the stems of Clausena lansium

Seven new carbazole alkaloids, claulansines L-R (1–7), and six known analogues (8–13) were isolated from the stems of Clausena lansium. Their structures were elucidated on the basis of spectroscopic analyses, including UV, IR, and NMR experiments (HSQC, HMBC, and NOE experiment). Compound 7 showed moderate anti-inflammatory activities. Compounds 3, 5, 6, 8, and 12 exhibited moderate hepatoprotective activities.

Graphical abstractSeven carbazole alkaloids, claulansines L-R (1–7), and six known analogues (8–13) were isolated from the stems of Clausena lansium. The following Figure is the structures of the new compounds 1–7.Figure optionsDownload full-size imageDownload high-quality image (126 K)Download as PowerPoint slide