| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538429 | Fitoterapia | 2015 | 6 Pages |
Abstract
Ambradiolic acid (3) with oleanane skeleton is a natural pentacyclictriterpene. The first synthesis of 3 starting from 23-hydroxybetulinic acid (2) has been accomplished in 12-steps with a total yield of 18.1% in our study. Compound 3 was further biologically evaluated and found to exhibit significant inhibitory activity against rabbit muscle glycogen phosphorylase (GP) with an IC50 value of 12.4 μM, suggesting it could be a potential lead compound for the development of hypoglycemic drugs.
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Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Jie Liu, Hengyuan Zhang, Peiqing Zhu, Xiaoming Wu, Hequan Yao, Wencai Ye, Jieyun Jiang, Jinyi Xu,