Cytotoxic and anti–inflammatory tirucallane triterpenoids from Dysoxylum binectariferum

Four new tirucallane triterpenoids 1–4 along with two known compounds 5 and 6 were isolated from the stem bark of Dysoxylum binectariferum. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for anti-inflammatory and cytotoxic potential against eight tumor cell lines. Compounds 1–6 exhibited significant selective inhibition of Cox-1 and selectively significant cytotoxic against five tumor cell lines (A-549, HCT15, HepG2, SGC-7901 and SK-MEL-2), especially against HepG2 cell lines with IC50 value of 7.5–9.5 μM.

Graphical abstractCytotoxic and anti-inflammatory tirucallane triterpenoids 1–6 were isolated from the stem bark of Dysoxylum binectariferum.Figure optionsDownload full-size imageDownload high-quality image (166 K)Download as PowerPoint slide