Salviprzols A and B, C21- and C22-terpenoids from the roots of Salvia przewalskii Maxim

Two C21- and C22-terpenoids, salviprzols A (1) and B (2), together with 24 known compounds including 17 diterpenoids (3–19), a triterpenoid (20), and 6 phenolic derivatives (21–26), were isolated from the roots of Salvia przewalskii Maxim. Salviprzols A and B represented a new subtype of C23-terpenoids featured by an additional 2-oxopropyl moiety at C-12 and a rare γ-hydroxyl-α-methyl-α,β-unsaturated-γ-lactone ring system. Their structures were elucidated by extensive spectroscopic analyses, and the structure of 2 was confirmed by a single-crystal X-ray diffraction crystallography. The cytotoxic activities of the new isolates were tested. A plausible biosynthetic pathway for 1 and 2 was also proposed.

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