Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata

Three new coumarin glucosides (1, 3, 4), and a new secoiridoid glucoside (2), together with one known secoiridoid glucoside (5), were isolated from the stems of Hydrangea paniculata. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. At 10 μM, compounds 1–5 showed hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells.

Graphical abstractNew coumarin glucoside and secoiridoid glucoside were isolated from the stems of Hydrangea paniculata. These compounds showed moderate hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells.Figure optionsDownload full-size imageDownload high-quality image (143 K)Download as PowerPoint slide