| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538591 | Fitoterapia | 2014 | 5 Pages |
Abstract
Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure–activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor biological activity.
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Xing-Xiu Chen, Feng Gao, Qi Wang, Xing Huang, Dan Wang,