Article ID Journal Published Year Pages File Type
2538647 Fitoterapia 2013 5 Pages PDF
Abstract

Three new 11,12,15-norbisabolane sesquiterpenoids, polisins A–C (1–3), and four new eremophilane sesquiterpenoids, polylisins A–D (4–7), were isolated from cultures of the Basidiomycete Polyporus ellisii. These new structures were elucidated based on extensive spectroscopic studies and the structures of polisin A (1) and polylisin A (4) were confirmed by single-crystal X-ray crystallographic analysis. All compounds were evaluated for their inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD1 and 11β-HSD2).

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (224 K)Download as PowerPoint slide

Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
Authors
, , , , ,