| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538652 | Fitoterapia | 2013 | 7 Pages |
Abstract
Five new diterpenoids named excocarinols A–E (1–5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58 μM and SI (Selection Index) over 112.71.
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Authors
Sheng-Zhuo Huang, Xuan Zhang, Qing-Yun Ma, Yong-Tang Zheng, Feng-Qing Xu, Hua Peng, Hao-Fu Dai, Jun Zhou, You-Xing Zhao,