| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538676 | Fitoterapia | 2012 | 4 Pages |
Abstract
Curcin is a ribosome-inactivating protein expressed in the endosperm of Jatropha curcas. Curcin can inhibit growth of mouse sarcoma-180 cells. At a curcin concentration of 100 μg/ml, mouse sarcoma-180 cell growth was inhibited by over 40% after seven days of incubation. Acridine orange staining and flow cytometry analysis also showed that the curcin could induce apoptosis of mouse sarcoma-180 cells. These observations provide a possible explanation for the anti-tumor properties of curcin.
Graphical abstractThe mouse sarcoma-180 cells undergoing apoptosis induced by curcin.Figure optionsDownload full-size imageDownload high-quality image (212 K)Download as PowerPoint slide
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Qi Zhao, Wenguo Wang, Yuehua Wang, Ying Xu, Fang Chen,