Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity

Five new cycloartane triterpenoids, schiglausins K–O (1–5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6–7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2–7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 μM.

Graphical abstractFive new cycloartane triterpenoids, together with two known compounds, were isolated from the stems of Schisandra glaucescens.Figure optionsDownload full-size imageDownload high-quality image (108 K)Download as PowerPoint slide