Article ID Journal Published Year Pages File Type
2538722 Fitoterapia 2012 4 Pages PDF
Abstract

Two new cyclopentene dialdehydes, tabebuialdehydes A and B (1 and 2) and a new dihydrocyclopenta[c]furan monoaldehyde, tabebuialdehyde C (3), along with ten known compounds were isolated from the roots of Tabebuia rosea. The structures of all isolated compounds were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with previous literature data. Moreover, all isolated compounds were evaluated for their cytotoxicity (KB and HeLa cell lines). Compounds 6, 7 and 9 showed significant cytotoxicity against both KB and HeLa cells with IC50 values of 1.35 and 1.15, 0.53 and 0.77, 1.79 and 0.73 μg/mL, respectively.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
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