Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas

Herba Epimedii is a well-known Botanical preparation used over long time in traditional Chinese medicine. The extracts and chemical constituents from Epimedium species are aphrodisiac as well as to treat many ailments. Chemical investigation of lonely species growing in Kashmir Himalaya Epimedium elatum was undertaken to evaluate its chemical profile. Two unusual substituted acylated flavonol glycosides named Elatoside A (1) and Elatoside B (2) have been isolated from the ethanolic extract of E. elatum along with 23 previously known ones (3–25). All isolates were evaluated for antimicrobial and PPAR-γ ligand binding activity, and some of them appeared to be modestly active.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (428 K)Download as PowerPoint slideHighlights► Epimedium elatum is one among species of genus Epimedium which is growing in India. ► The chemistry of Epimedium elatum was investigated, with 25 compounds isolated. ► New compounds are acylated flavonol glycosides; elatoside A and elatoside B. ► Antimicrobial and PPAR-γ ligand binding activity of pure compounds.