Macrocyclic diterpenoids from the Iranian plant Euphorbia bungei Boiss.

An acetone extract from the aerial parts of Euphorbia bungei afforded three new (2, 3 and 5) and one known (4) macrocyclic diterpenoids. Several cycloartane triterpenoids were also obtained, two of which (6a and 6b) were assayed for antiviral effects. The structures of all new compounds were elucidated using modern spectroscopic methods including 2D NMR and HRMS.

Graphical abstractThree new macrocyclic diterpenoids (two jatrophanes and a lathyrane), along with several cycloartane triterpenoids, have been isolated from the Iranian hardy spurge Euphorbia bungei Boiss.Figure optionsDownload full-size imageDownload as PowerPoint slide