| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538851 | Fitoterapia | 2011 | 8 Pages |
Schisandrin B (Sch B) and schisandrin C (Sch C), but not schisandrin A and dimethyl diphenyl bicarboxylate, protected rat skin tissue against solar irradiation-induced oxidative injury, as evidenced by a reversal of solar irradiation-induced changes in cellular reduced glutathione and α-tocopherol levels, as well as antioxidant enzyme activities and malondialdehyde production. The cytochrome P-450-mediated metabolism of Sch B or Sch C caused ROS production in rat skin microsomes. Taken together, Sch B or Sch C, by virtue of its pro-oxidant action and the subsequent eliciting of a glutathione antioxidant response, may prevent photo-aging of skin.
Graphical AbstractExperimental setting for solar-irradiation on rat skin.Figure optionsDownload full-size imageDownload as PowerPoint slide
