| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538860 | Fitoterapia | 2011 | 8 Pages |
Abstract
The oral bioavailability of vasicine (1) was investigated in hard gelatin capsules of lyophilized Vasa Swaras (aqueous extract of Adhatoda vasica Nees.,Fam.: Acanthaceae) The rat pharmacokinetic profile of lyophilized Vasa Swaras, Vasa Swaras, vasicine (1) (chief marker compounds of A. vasica) and a marketed capsule formulation of A. vasica were compared. Vasicine (1) was found to be more orally bioavailable from lyophilized Vasa Swaras, with an overall minor conversion to vasicinone (2).
Graphical AbstractMean (± SD) plasma concentration of vasicine upon oral administration of lyophilized Vasa Swaras, vasicine, marketed formulation of A. vasica and Vasa Swaras capsules.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Tejas Vyas, Ranjeet Prasad Dash, Sheetal Anandjiwala, Manish Nivsarkar,