Macrostachyols A–D, new oligostilbenoids from the roots of Gnetum macrostachyum

Four new oligostilbenes, macrostachyols A–D (1–4) along with six known stilbenoids (5–10), were isolated from the roots of Gnetum macrostachyum. These compounds were also evaluated for their cytotoxicity towards HeLa and KB cell lines. Only compound 4 showed the significant cytotoxicity to HeLa cells with IC50 value of 4.13 μM.

Graphical AbstractFour new oligostilbenes, macrostachyols A–D (1–4) along with six known stilbenoids, were isolated from the roots of Gnetum macrostachyum. Their structures were established on the basis of spectroscopic methods and these compounds were also evaluated for their cytotoxicity towards HeLa and KB cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide