Article ID Journal Published Year Pages File Type
2538864 Fitoterapia 2011 7 Pages PDF
Abstract

Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety.We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity, namely the effects on synaptic uptake of serotonin and the forced-swimming-test. We show here for the first time, that Passiflora significantly enhances the pharmacological potency of Hypericum in both models.Our data suggest that anti-depressive therapeutic effects of Hypericum are possible with lower doses, when it is combined with Passiflora, than with mono-preparations of Hypericum.

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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
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