Aphagrandinoids A–D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia

Three new cycloartane triterpenoids, aphagrandinoids A–C (1–3), and a new natural product, aphagrandinoid D (4), together with a known compound, were isolated from the leaves and twigs of Aphanamixis grandifolia. Their structures were elucidated by extensive NMR and MS techniques. Aphagrandinoid A (1), a 29-nor-cycloart triterpenoid, features with a sprio ring system at the side chain, while aphagrandinoid C (3) is a pentnortriterpenoid. Antibacterial activities of these five compounds were also evaluated. Compounds 1 and 5 showed weak antibacterial activities (MIC values: 1.57–3.13 μg/mL) against Staphylococcus aureus, MRSA 92#, and MRSA 98#.

Graphical abstractThree new cycloartane triterpenoids, aphagrandinoids A–C (1–3), and a new natural product, aphagrandinoid D (4), together with a known compound (5), were isolated from the leaves and twigs of Aphanamixis grandifolia.Figure optionsDownload full-size imageDownload high-quality image (141 K)Download as PowerPoint slide