Antioxidant flavanes from Livistona chinensis

Three new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. The structure of the new flavanes were established as 2S,3S-3,5,7,3′,5′-pentahydroxyflavane (1), 2R,3R-3,5,6,7,8,4′-hexahydroxyflavane (2) and 2R,3R-3,5,6,7,8,3′,5′-heptahydroxyflavane (3), respectively, on the basis of chemical and spectroscopic data. The antiproliferative activity against four human tumor cell lines (HL-60, Mata, HepG2 and CNE-1) was evaluated. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC50 of 0.2 ± 0.01 and 1.0 ± 0.1 μM, respectively, overpowering the reference compound in the assay (cisplatin). Most compounds also exhibited potent antioxidant activity.

Graphical AbstractThree new flavanes and eight known flavonoids were isolated from the fruits of Livistona chinensis. 1 had significantly antiproliferative effects against HL-60 and CNE-1 with the IC50 of 0.2 ± 0.01 and 1.0 ± 0.1 μM, respectively, overpowering the reference compound in the assay (cisplatin).Figure optionsDownload full-size imageDownload as PowerPoint slide