Phytochemical potential of Eruca sativa for inhibition of melanoma tumor growth

Solvent extracts from the aerial and root parts and seed oil from E. sativa (rocket salad) were assayed for anticancer activity against melanoma cells. The seed oil (isothiocyanates rich) significantly (p < 0.01) reduced the tumor growth comparable to the control. Remarkably, the seed oil inhibited melanoma growth and angiogenesis in mice without any major toxicity. The findings qualify seed oil for further investigations in the real of cancer prevention and treatment.

Graphical abstractSeed oil (isothiocyanates) of the plant E. sativa showed the inhibition of melanoma cell line (95.11%: 100 μg/ml) while significantly reduced the tumor growth (29.48%: 2 mg) in mice.Figure optionsDownload full-size imageDownload as PowerPoint slide