Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects

Roots of Morinda citrifolia (Noni or Yor in Thai) have been used traditionally for thousands of years to treat chronic diseases such as cancer and heart disease. In this study, three new anthraquinones together with 15 known compounds were isolated from the roots of M. citrifolia (Rubiaceae). Their structures were established by spectroscopic methods, particularly 1D and 2D NMR techniques. Six known compounds, together with two new compounds (2 and 3) showed significant inhibitory effects on the proliferation of human lung and colon cancer cells.

Graphical abstractTwo plausible stereochemical configurations of Nonin B were identified in noni root.Figure optionsDownload full-size imageDownload as PowerPoint slide