| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2538983 | Fitoterapia | 2012 | 8 Pages |
In the present study, the antimicrobial activity of glycyrrhetinic acid (GA) against Staphylococcus aureus, and its influence on the production of S. aureus alpha-haemolysin (Hla) were investigated, along with the in vivo activity of GA against S. aureus-induced pneumonia. GA could not inhibit the growth of S. aureus, but the secretion of Hla by S. aureus was significantly inhibited by low concentrations of GA in a dose-dependent manner. Furthermore, in vivo data show that GA provides protection against staphylococcal pneumonia in a murine model system.
Graphical abstractGlycyrrhetinic acid dose-dependently reduces the production of alpha-haemolysin by Staphylococcus aureus, and thereby alleviates lung injury caused by S. aureus pneumonia.Figure optionsDownload full-size imageDownload high-quality image (268 K)Download as PowerPoint slide
