Chromones and coumarins from the dried fructus of Cnidium monnieri

Chemical investigations on the ethanolic extract of the dried fructus of Cnidium monnieri offered three chromones and eight coumarins. Among them, a new chromone and a new coumarin were identified and elucidated as 5,7-dihydroxy-6-[(2Z)-4-(β-d-glucopyranosyl)oxy-3- methylbut-2-enyl]-2-hydroxymethyl-4H-1-benzopyran-4-one (1, hydroxycnidimoside A) and (rel 1′S,2′R)-8-(2,3-epoxy-1-hydroxy-3-methylbutyl)-7-methoxycoumarin (8, hydroxyosthole epoxide), respectively, by extensive analyses of spectroscopic data including 1- and 2-D NMR, MS, UV, OR, IR, and HRMS data. The other known compounds were identified by analyses of spectroscopic data and by comparison with literature reported.

Graphical abstractA new chromone and a new coumarin were isolated from the ethanolic extract of the dried fructus of Cnidium monnieri. Their structures were identified and elucidated as 5,7-dihydroxy-6-[(2Z)-4-(β-d-glucopyranosyl)oxy-3-methylbut-2-enyl]-2-hydroxymethyl-4H-1-benzopyran-4-one and (rel 1′S,2′R)-8-(2,3- epoxy-1-hydroxy-3-methylbutyl)-7- methoxycoumarin, respectively, by extensive analyses of spectroscopic data.Figure optionsDownload full-size imageDownload as PowerPoint slide