A new cytotoxic flavonoid from the fruit of Sinopodophyllum hexandrum

Constituents of the fruit of Sinopodophyllum hexandrum (Royle) Ying (Sinopodophylli Fructus) were investigated. A new flavonoid, 8,2′-diprenylquercetin 3-methyl ether along with 9 known compounds were isolated and identified. Among them, the new compound 8,2′-diprenylquercetin 3-methyl ether exhibited cytotoxic activities against MDA-231 and T47D breast cancer cell lines, quercetin, kaempferol and rutin were isolated from Sinopodophylli Fructus for the first time.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide8,2′-diprenylquercetin 3-methyl ether′s structure and the growth inhibition rate against MDA-231 and T47D in 48 h (%).SampleDosage (µmol/L)MDA-231T47D1− 1.864.9558.04− 6.931012.58− 7.92Compound 12536.2925.745067.8481.1910098.5692.08Taxol2.332.9990.10Full-size tableTable optionsView in workspaceDownload as CSV